Bibliotecas PUC-SP - Busca Integrada

P331: THE ONCOGENIC TRANSCRIPTION FACTOR TCF3::HLF MARKS A DISTINCT ENHANCER-PROMOTER INTERACTION NETWORK IN T(17;19) POSITIVE CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

por Valdemar Priebe, Aneta Drakul, Stefan Zeyen, Beat Bornhauser, Raffaella Santoro, Jean-Pierre Bourquin
Publicado en HemaSphere (2023-08-01)

Rapid Generation of Leukemogenic Chromosomal Translocations in Vivo Using CRISPR/Cas9

por Yun Huang, Blerim Marovca, Susanne Dettwiler, Peter Karl Bode, Beat Bornhauser, Jean-Pierre Bourquin
Publicado en HemaSphere (2020-10-01)

MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling

por Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K. Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin
Publicado en SLAS Discovery (2023-10-01)

High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors

por Lenka Besse, Andrej Besse, Marianne Kraus, Elmer Maurits, Herman S. Overkleeft, Beat Bornhauser, Jean-Pierre Bourquin, Christoph Driessen
Publicado en Cells (2021-10-01)

Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

por Lena Behrmann, Scott McComb, Júlia Aguadé-Gorgorió, Yun Huang, Mario Hermann, Pawel Pelczar, Adriano Aguzzi, Jean Bourquin, Beat Bornhauser
Publicado en Bio-Protocol (2017-04-01)

BH3-MIMETIC TREATMENT REVEALS SUBTYPE-SPECIFIC BCL-2 PROTEIN DEPENDENCY IN PEDIATRIC MDS WITH EXCESS BLASTS

por Sheila Bohler, Ayami Yoshimi Nöllke, Nastassja Scheidegger, Ben Haladik, Beat Bornhauser, Michael N. Dworzak, Kaan Boztug, Markus Schmugge, Charlotte M. Niemeyer, Miriam Erlacher
Publicado en EJC Paediatric Oncology (2025-12-01)

Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia

por Julia Costea, Kerstin K. Rauwolf, Pietro Zafferani, Tobias Rausch, Anna Mathioudaki, Judith Zaugg, Martin Schrappe, Cornelia Eckert, Gabriele Escherich, Jean P. Bourquin, Beat Bornhauser, Andreas E. Kulozik, Jan O. Korbel
Publicado en Nature Communications (2025-06-01)

Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia

por Marketa Zaliova, Eliska Potuckova, Julius Lukes, Lucie Winkowska, Julia Starkova, Iveta Janotova, Lucie Sramkova, Jan Stary, Jan Zuna, Martin Stanulla, Martin Zimmermann, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Gunnar Cario, Jan Trka
Publicado en Haematologica (2020-06-01)

B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow

por Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin
Publicado en Haematologica (2022-11-01)

SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

por Nurul Khalida Ibrahim, Sabine Schreek, Buesra Cinar, Anna Sophie Stasche, Su Hyun Lee, Andre Zeug, Tim Dolgner, Julia Niessen, Evgeni Ponimaskin, Halyna Shcherbata, Beate Fehlhaber, Jean-Pierre Bourquin, Beat Bornhauser, Martin Stanulla, Andreas Pich, Alejandro Gutierrez, Laura Hinze
Publicado en Cell Reports (2025-04-01)

P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS

por Rebecca Hasselmann, Lena Blümel, Flavia Bernardi, Daniel Picard, Jacob Torrejon-Diaz, Vera Jepsen, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovca, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourquin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer
Publicado en HemaSphere (2023-08-01)

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12

por Selina Troester, Thomas Eder, Nadja Wukowits, Martin Piontek, Pablo Fernández-Pernas, Johannes Schmoellerl, Ben Haladik, Gabriele Manhart, Melanie Allram, Margarita Maurer-Granofszky, Nastassja Scheidegger, Karin Nebral, Giulio Superti-Furga, Roland Meisel, Beat Bornhauser, Peter Valent, Michael N. Dworzak, Johannes Zuber, Kaan Boztug, Florian Grebien
Publicado en Nature Communications (2025-05-01)

ADVANCED DRUG RESPONSE PROFILING AND IMMUNOPHENOTYPING TO PRIORITIZE TREATMENT OPTIONS FOR PEDIATRIC MDS WITH EXCESS BLASTS

por Ben Haladik, Margarita Maurer-Granofszky, Anna Hurt, Claudia M. Koelbl, Nastassja Scheidegger, Silvia Gutnik, Fabio Steffen, Barbara De Moerloose, Henrik Hasle, Marek Ussowicz, Luca Vinci, Ayami Yoshimi Noellke, Jean-Pierre Bourquin, Charlotte Niemeyer, Markus Schmugge, Beat Bornhauser, Miriam Erlacher, Michael N. Dworzak, Kaan Boztug
Publicado en EJC Paediatric Oncology (2025-12-01)

Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia

por Lena Blumel, Flavia Bernardi, Daniel Picard, Jacob Torrejon Diaz, Vera H. Jepsen, Rebecca Hasselmann, Julian Schliehe-Diecks, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovka, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourqin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer
Publicado en Haematologica (2024-02-01)

INTEGRATED IMMUNOPHENOTYPING AND DRUG RESPONSE PROFILING REVEALS SUBTYPE-SPECIFIC SUSCEPTIBILITIES IN PEDIATRIC MDS WITH EXCESS BLASTS

por Nastassja Scheidegger-Egloff, Silvia Gutnik, Claudia Moeller, Fabio Steffen, Arianna Arpagaus, Larissa Schori, Selina Schuehle, Sheila Bohler, Ben Haladik, Anna Hurt, Claudia M. Koebl, Margarita Maurer Granofszky, Barbara De Moerloose, Henrik Hasle, Charlotte Niemeyer, Marek Ussowicz, Luca Vinci, Ayami Yoshimi-Noellke, Kaan Boztug, Michael N. Dworzak, Jean-Pierre Bourquin, Miriam Erlacher, Markus Schmugge, Beat Bornhauser
Publicado en EJC Paediatric Oncology (2025-12-01)

PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia

por Paulina Richter‐Pechańska, Joachim B Kunz, Beat Bornhauser, Caroline von Knebel Doeberitz, Tobias Rausch, Büşra Erarslan‐Uysal, Yassen Assenov, Viktoras Frismantas, Blerim Marovca, Sebastian M Waszak, Martin Zimmermann, Julia Seemann, Margit Happich, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Martina U Muckenthaler, Jan O Korbel, Jean‐Pierre Bourquin, Andreas E Kulozik
Publicado en EMBO Molecular Medicine (2018-11-01)

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

por Büşra Erarslan‐Uysal, Joachim B Kunz, Tobias Rausch, Paulina Richter‐Pechańska, Ianthe AEM van Belzen, Viktoras Frismantas, Beat Bornhauser, Diana Ordoñez‐Rueada, Malte Paulsen, Vladimir Benes, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Tsvetomir Loukanov, Matthias Gorenflo, Sebastian M Waszak, Jean‐Pierre Bourquin, Martina U Muckenthaler, Jan O Korbel, Andreas E Kulozik
Publicado en EMBO Molecular Medicine (2020-08-01)

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

por Obul R. Bandapalli, Stephanie Schuessele, Joachim B. Kunz, Tobias Rausch, Adrian M. Stütz, Noa Tal, Ifat Geron, Nava Gershman, Shai Izraeli, Juliane Eilers, Nina Vaezipour, Renate Kirschner-Schwabe, Jana Hof, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Martin Zimmermann, Rolf Koehler, Smadar Avigad, Rupert Handgretinger, Viktoras Frismantas, Jean Pierre Bourquin, Beat Bornhauser, Jan O. Korbel, Martina U. Muckenthaler, Andreas E. Kulozik
Publicado en Haematologica (2014-10-01)

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets

por Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel
Publicado en Blood Advances (2019-10-01)

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

por Renate De Smedt, Sofie Peirs, Julie Morscio, Filip Matthijssens, Juliette Roels, Lindy Reunes, Beatrice Lintermans, Steven Goossens, Tim Lammens, Nadine Van Roy, Aurore Touzart, Silvia Jenni, Yi-Chien Tsai, Federica Lovisa, Lara Mussolin, Valentina Serafin, Filip Van Nieuwerburgh, Dieter Deforce, Anne Uyttebroeck, Thomas Tousseyn, Birgit Burkhardt, Wolfram Klapper, Barbara De Moerloose, Yves Benoit, Elizabeth Macintyre, Jean-Pierre Bourquin, Giuseppe Basso, Benedetta Accordi, Beat Bornhauser, Jules Meijerink, Peter Vandenberghe, Pieter Van Vlierberghe
Publicado en Haematologica (2019-01-01)