The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy

Tumors have a huge impact on human life and are now the main cause of disease-related deaths. The main means of treatment are surgery and radiotherapy, but they are more damaging to the organism and have a poor postoperative prognosis. Therefore, we urgently need safe and effective drugs to treat tu...

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Publicado no:Molecules
Principais autores: Yating Yang, Ling Yuan, Kaili Wang, Doudou Lu, Fandi Meng, Duojie Xu, Weiqiang Li, Yi Nan
Formato: Artigo
Publicado em: MDPI AG 2024-03-01
Assuntos:
<i>Paeoniae Radix Alba</i>
Tumor therapy
Medicine and food homology
Molecular mechanism
Acesso em linha:https://www.mdpi.com/1420-3049/29/7/1424
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spelling doaj-art-df00ae9bb5c84eb5b8e44a72da2dceb42025-08-20T00:14:44ZengMDPI AGMolecules1420-30492024-03-01297142410.3390/molecules29071424The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor TherapyYating Yang0Ling Yuan1Kaili Wang2Doudou Lu3Fandi Meng4Duojie Xu5Weiqiang Li6Yi Nan7Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaTraditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, ChinaKey Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, ChinaTraditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Chinese Medical Gastrointestinal, The Affiliated TCM Hospital, Ningxia Medical University, Wuzhong 751100, ChinaKey Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, ChinaTumors have a huge impact on human life and are now the main cause of disease-related deaths. The main means of treatment are surgery and radiotherapy, but they are more damaging to the organism and have a poor postoperative prognosis. Therefore, we urgently need safe and effective drugs to treat tumors. In recent years, Chinese herbal medicines have been widely used in tumor therapy as complementary and alternative therapies. Medicinal and edible herbs are popular and have become a hot topic of research, which not only have excellent pharmacological effects and activities, but also have almost no side effects. Therefore, as a typical medicine and food homology, some components of <i>Paeoniae Radix Alba</i> (PRA, called Baishao in China) have been shown to have good efficacy and safety against cancer. Numerous studies have also shown that <i>Paeoniae Radix Alba</i> and its active ingredients treat cancer through various pathways and are also one of the important components of many antitumor herbal compound formulas. In this paper, we reviewed the literature on the intervention of <i>Paeoniae Radix Alba</i> in tumors and its mechanism of action in recent years and found that there is a large amount of literature on its effect on total glucosides of paeony (TGP) and paeoniflorin (PF), as well as an in-depth discussion of the mechanism of action of <i>Paeoniae Radix Alba</i> and its main constituents, with a view to promote the clinical development and application of <i>Paeoniae Radix Alba</i> in the field of antitumor management.https://www.mdpi.com/1420-3049/29/7/1424<i>Paeoniae Radix Alba</i>tumor therapymedicine and food homologymolecular mechanism
institution Directory of Open Access Journals
collection DOAJ
format Article
author Yating Yang
Ling Yuan
Kaili Wang
Doudou Lu
Fandi Meng
Duojie Xu
Weiqiang Li
Yi Nan
spellingShingle Yating Yang
Ling Yuan
Kaili Wang
Doudou Lu
Fandi Meng
Duojie Xu
Weiqiang Li
Yi Nan
The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy
Molecules
10.3390/molecules29071424
<i>Paeoniae Radix Alba</i>
Tumor therapy
Medicine and food homology
Molecular mechanism
author_facet Yating Yang
Ling Yuan
Kaili Wang
Doudou Lu
Fandi Meng
Duojie Xu
Weiqiang Li
Yi Nan
author_sort Yating Yang
title The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy
title_short The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy
title_full The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy
title_fullStr The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy
title_full_unstemmed The Role and Mechanism of <i>Paeoniae Radix Alba</i> in Tumor Therapy
title_sort role and mechanism of <i>paeoniae radix alba</i> in tumor therapy
publisher MDPI AG
publisher_facet MDPI AG
container_title Molecules
container_title_facet Molecules
issn 1420-3049
publishDate 2024-03-01
container_volume 29
container_issue 7
container_startPage 1424
doi 10.3390/molecules29071424
description Tumors have a huge impact on human life and are now the main cause of disease-related deaths. The main means of treatment are surgery and radiotherapy, but they are more damaging to the organism and have a poor postoperative prognosis. Therefore, we urgently need safe and effective drugs to treat tumors. In recent years, Chinese herbal medicines have been widely used in tumor therapy as complementary and alternative therapies. Medicinal and edible herbs are popular and have become a hot topic of research, which not only have excellent pharmacological effects and activities, but also have almost no side effects. Therefore, as a typical medicine and food homology, some components of <i>Paeoniae Radix Alba</i> (PRA, called Baishao in China) have been shown to have good efficacy and safety against cancer. Numerous studies have also shown that <i>Paeoniae Radix Alba</i> and its active ingredients treat cancer through various pathways and are also one of the important components of many antitumor herbal compound formulas. In this paper, we reviewed the literature on the intervention of <i>Paeoniae Radix Alba</i> in tumors and its mechanism of action in recent years and found that there is a large amount of literature on its effect on total glucosides of paeony (TGP) and paeoniflorin (PF), as well as an in-depth discussion of the mechanism of action of <i>Paeoniae Radix Alba</i> and its main constituents, with a view to promote the clinical development and application of <i>Paeoniae Radix Alba</i> in the field of antitumor management.
topic <i>Paeoniae Radix Alba</i>
Tumor therapy
Medicine and food homology
Molecular mechanism
topic_facet <i>Paeoniae Radix Alba</i>
Tumor therapy
Medicine and food homology
Molecular mechanism
url https://www.mdpi.com/1420-3049/29/7/1424
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first_indexed 2025-09-11T09:49:03Z
last_indexed 2025-09-11T09:49:03Z
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