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Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles
Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines. Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized...
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| Julkaisussa: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Aineistotyyppi: | Artikkeli |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-08-01
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| Linkit: | http://pharmed.zsmu.edu.ua/article/view/45130/43759 |
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doaj-art-e0ce9978b5d149a68f3bc98f2e4530ac2025-08-20T02:51:03ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322015-08-012212410.14739/2409-2932.2015.2.45130Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazolesO. A. SuhakO. I. PanasenkoYe. G. KnyshAim. Selection, synthesis and biological properties of new compound play major role in creating original medicines. Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized, by alkylation reaction of 4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thiols with 1-bromobutane, or 1-bromopentane, or 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodekane in the n-butanol medium and their physical-chemical properties have been studied using modern physical-chemical methods of analysis, elemental analysis, IR spectroscopy, and their individuality using HPLC-MS. Conclusion. This suggests the possibility of further studying the biological effect of the synthesized compounds.http://pharmed.zsmu.edu.ua/article/view/45130/437591 2 4-triazolesIR-spectroscopyHPLC-mass SpectrometrySynthesis |
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Directory of Open Access Journals |
| collection |
DOAJ |
| format |
Article |
| author |
O. A. Suhak O. I. Panasenko Ye. G. Knysh |
| spellingShingle |
O. A. Suhak O. I. Panasenko Ye. G. Knysh Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki 10.14739/2409-2932.2015.2.45130 1 2 4-triazoles IR-spectroscopy HPLC-mass Spectrometry Synthesis |
| author_facet |
O. A. Suhak O. I. Panasenko Ye. G. Knysh |
| author_sort |
O. A. Suhak |
| title |
Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_short |
Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_full |
Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_fullStr |
Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_full_unstemmed |
Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_sort |
synthesis and physical-chemical properties of 3-(alkylthio)-4-r-5-(thiophen-2-ylmethyl)-4h-1,2,4-triazoles |
| publisher |
Zaporizhzhia State Medical and Pharmaceutical University |
| publisher_facet |
Zaporizhzhia State Medical and Pharmaceutical University |
| container_title |
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| container_title_facet |
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| issn |
2306-8094 2409-2932 |
| publishDate |
2015-08-01 |
| container_issue |
2 |
| container_startPage |
21 |
| container_endPage |
24 |
| doi |
10.14739/2409-2932.2015.2.45130 |
| description |
Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines.
Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized, by alkylation reaction of 4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thiols with 1-bromobutane, or 1-bromopentane, or 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodekane in the n-butanol medium and their physical-chemical properties have been studied using modern physical-chemical methods of analysis, elemental analysis, IR spectroscopy, and their individuality using HPLC-MS.
Conclusion. This suggests the possibility of further studying the biological effect of the synthesized compounds. |
| topic |
1 2 4-triazoles IR-spectroscopy HPLC-mass Spectrometry Synthesis |
| topic_facet |
1 2 4-triazoles IR-spectroscopy HPLC-mass Spectrometry Synthesis |
| url |
http://pharmed.zsmu.edu.ua/article/view/45130/43759 |
| work_keys_str_mv |
AT oasuhak synthesisandphysicalchemicalpropertiesof3alkylthio4r5thiophen2ylmethyl4h124triazoles AT oipanasenko synthesisandphysicalchemicalpropertiesof3alkylthio4r5thiophen2ylmethyl4h124triazoles AT yegknysh synthesisandphysicalchemicalpropertiesof3alkylthio4r5thiophen2ylmethyl4h124triazoles |
| first_indexed |
2023-04-09T04:58:07Z |
| last_indexed |
2025-09-03T12:21:34Z |
| _version_ |
1851032849277255680 |