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Vitamin D Status and Mortality: A Systematic Review of Observational Studies
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality, but it is unclear whether this is explained by reverse causation, and if there are specific causes of death for which vitamin D might be important. We conducted a systematic review of observational st...
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| Τόπος έκδοσης: | International Journal of Environmental Research and Public Health |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Άρθρο |
| Έκδοση: |
MDPI AG
2019-01-01
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| Διαθέσιμο Online: | https://www.mdpi.com/1660-4601/16/3/383 |
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doaj-art-e4aa78fbb4e943deaf421913af19cd0a2022-12-21T18:43:19ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-01-0116338310.3390/ijerph16030383ijerph16030383Vitamin D Status and Mortality: A Systematic Review of Observational StudiesAlicia K Heath0Iris Y Kim1Allison M Hodge2Dallas R English3David C Muller4School of Public Health, Imperial College London, London W2 1PG, UKDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USACentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, AustraliaCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, AustraliaSchool of Public Health, Imperial College London, London W2 1PG, UKEpidemiological evidence suggests that vitamin D deficiency is associated with increased mortality, but it is unclear whether this is explained by reverse causation, and if there are specific causes of death for which vitamin D might be important. We conducted a systematic review of observational studies investigating associations between circulating 25-hydroxyvitamin D (25(OH)D) concentration and all-cause or cause-specific mortality in generally healthy populations. Relevant studies were identified using PubMed and EMBASE searches. After screening 722 unique records and removing those that were ineligible, 84 articles were included in this review. The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality. This association appeared to be non-linear, with progressively lower mortality with increasing 25(OH)D up to a point, beyond which there was no further decrease. There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases, while for cardiovascular mortality, there is weak evidence of an association in observational studies, which is not supported by the data from intervention or Mendelian randomization studies. The relationship between vitamin D status and other causes of death remains uncertain due to limited data. Larger long-term studies are required to clarify these associations.https://www.mdpi.com/1660-4601/16/3/383vitamin Dvitamin D status25-hydroxyvitamin Dmortalityall-cause mortalitycause-specific mortalitycancer mortalitycardiovascular mortalityrespiratory disease mortalitysystematic review |
| institution |
Directory of Open Access Journals |
| collection |
DOAJ |
| format |
Article |
| author |
Alicia K Heath Iris Y Kim Allison M Hodge Dallas R English David C Muller |
| spellingShingle |
Alicia K Heath Iris Y Kim Allison M Hodge Dallas R English David C Muller Vitamin D Status and Mortality: A Systematic Review of Observational Studies International Journal of Environmental Research and Public Health 10.3390/ijerph16030383 Vitamin D Vitamin D status 25-hydroxyvitamin D Mortality All-cause mortality Cause-specific mortality Cancer mortality Cardiovascular mortality Respiratory disease mortality Systematic review |
| author_facet |
Alicia K Heath Iris Y Kim Allison M Hodge Dallas R English David C Muller |
| author_sort |
Alicia K Heath |
| title |
Vitamin D Status and Mortality: A Systematic Review of Observational Studies |
| title_short |
Vitamin D Status and Mortality: A Systematic Review of Observational Studies |
| title_full |
Vitamin D Status and Mortality: A Systematic Review of Observational Studies |
| title_fullStr |
Vitamin D Status and Mortality: A Systematic Review of Observational Studies |
| title_full_unstemmed |
Vitamin D Status and Mortality: A Systematic Review of Observational Studies |
| title_sort |
vitamin d status and mortality: a systematic review of observational studies |
| publisher |
MDPI AG |
| publisher_facet |
MDPI AG |
| container_title |
International Journal of Environmental Research and Public Health |
| container_title_facet |
International Journal of Environmental Research and Public Health |
| issn |
1660-4601 |
| publishDate |
2019-01-01 |
| container_volume |
16 |
| container_issue |
3 |
| container_startPage |
383 |
| doi |
10.3390/ijerph16030383 |
| description |
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality, but it is unclear whether this is explained by reverse causation, and if there are specific causes of death for which vitamin D might be important. We conducted a systematic review of observational studies investigating associations between circulating 25-hydroxyvitamin D (25(OH)D) concentration and all-cause or cause-specific mortality in generally healthy populations. Relevant studies were identified using PubMed and EMBASE searches. After screening 722 unique records and removing those that were ineligible, 84 articles were included in this review. The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality. This association appeared to be non-linear, with progressively lower mortality with increasing 25(OH)D up to a point, beyond which there was no further decrease. There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases, while for cardiovascular mortality, there is weak evidence of an association in observational studies, which is not supported by the data from intervention or Mendelian randomization studies. The relationship between vitamin D status and other causes of death remains uncertain due to limited data. Larger long-term studies are required to clarify these associations. |
| topic |
Vitamin D Vitamin D status 25-hydroxyvitamin D Mortality All-cause mortality Cause-specific mortality Cancer mortality Cardiovascular mortality Respiratory disease mortality Systematic review |
| topic_facet |
Vitamin D Vitamin D status 25-hydroxyvitamin D Mortality All-cause mortality Cause-specific mortality Cancer mortality Cardiovascular mortality Respiratory disease mortality Systematic review |
| url |
https://www.mdpi.com/1660-4601/16/3/383 |
| work_keys_str_mv |
AT aliciakheath vitamindstatusandmortalityasystematicreviewofobservationalstudies AT irisykim vitamindstatusandmortalityasystematicreviewofobservationalstudies AT allisonmhodge vitamindstatusandmortalityasystematicreviewofobservationalstudies AT dallasrenglish vitamindstatusandmortalityasystematicreviewofobservationalstudies AT davidcmuller vitamindstatusandmortalityasystematicreviewofobservationalstudies |
| first_indexed |
2023-04-07T00:38:16Z |
| last_indexed |
2023-04-07T00:38:16Z |
| _version_ |
1765160915780501504 |