Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages

A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described. The phosphorodithioate linkage is introduced using a new dithiophosphorylating reagent DPSE-SP(S)Cl(2) where DPSE = 2-diphenylmethylsilylethyl. This group is removed quickly using tetra-butylammonium fluor...

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Autors principals:	Capaldi, Daniel C., Cole, Douglas L., Ravikumar, Vasulinga T.
Format:	Article
Idioma:	en
Publicat:	Oxford University Press 2000
Matèries:	NAR Methods Online
Accés en línia:	https://ncbi.nlm.nih.gov/pmc/articles/PMC103313/ https://ncbi.nlm.nih.gov/pubmed/10756207
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