A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection

Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf −/−) mice chronically infected with lymphocytic choriomeningitis virus (LCMV) contained greater numbers of antiviral T cells compared...

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Bibliographic Details
Main Authors: Matloubian, Mehrdad, Suresh, M., Glass, Alison, Galvan, Marisa, Chow, Kit, Whitmire, Jason K., Walsh, Craig M., Clark, William R., Ahmed, Rafi
Format: Article
Language:en
Published: American Society for Microbiology 1999
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC104500/
https://ncbi.nlm.nih.gov/pubmed/9971838
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https://ncbi.nlm.nih.gov/pmc/articles/PMC104500/
https://ncbi.nlm.nih.gov/pubmed/9971838

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