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Circumvention of Immunity to the Adenovirus Major Coat Protein Hexon

Immunity to adenoviruses is an important hurdle to be overcome for successful gene therapy. The presence of antibodies to the capsid proteins prevents efficacious adenovirus vector administration in vivo. We tested whether immunity to a particular serotype of adenovirus (Ad5) may be overcome with a...

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Detalles Bibliográficos
Autores principales: Roy, Soumitra, Shirley, Pamela S., McClelland, Alan, Kaleko, Michael
Formato: Artículo
Lenguaje:en
Publicado: American Society for Microbiology 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC109897/
https://ncbi.nlm.nih.gov/pubmed/9658137
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