Utilization of Chimeras between Human (HM-175) and Simian (AGM-27) Strains of Hepatitis A Virus To Study the Molecular Basis of Virulence

Chimeras between human (HM-175) and simian (AGM-27) strains of hepatitis A virus (HAV) were constructed to evaluate the effect of the 2C gene of AGM-27 on HAV replication in cell culture and virulence in tamarins (Saguinus mystax) and chimpanzees (Pan troglodytes). Kinetic studies and radioimmunofoc...

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Bibliographic Details
Main Authors: Raychaudhuri, Gopa, Govindarajan, Sugantha, Shapiro, Max, Purcell, Robert H., Emerson, and Suzanne U.
Format: Article
Language:en
Published: American Society for Microbiology 1998
Subjects:
Viral Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109981/
https://ncbi.nlm.nih.gov/pubmed/9696843
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https://ncbi.nlm.nih.gov/pmc/articles/PMC109981/
https://ncbi.nlm.nih.gov/pubmed/9696843

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