Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression

We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the t...

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Main Authors: Islam, Sabina A., Hay, Christine M., Hartman, Kelly E., He, Suqin, Shea, Amy K., Trocha, Alicja K., Dynan, Mark J., Reshamwala, Neha, Buchbinder, Susan P., Basgoz, Nesli O., Kalams, Spyros A.
Formato: Artigo
Idioma:en
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114246/
https://ncbi.nlm.nih.gov/pubmed/11312363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.10.4907-4911.2001
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spelling pubmed-1142462002-09-13 Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression Islam, Sabina A. Hay, Christine M. Hartman, Kelly E. He, Suqin Shea, Amy K. Trocha, Alicja K. Dynan, Mark J. Reshamwala, Neha Buchbinder, Susan P. Basgoz, Nesli O. Kalams, Spyros A. J Virol Pathogenesis and Immunity We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection. American Society for Microbiology 2001-05 /pmc/articles/PMC114246/ /pubmed/11312363 http://dx.doi.org/10.1128/JVI.75.10.4907-4911.2001 Text en Copyright © 2001, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Pathogenesis and Immunity
spellingShingle Pathogenesis and Immunity
Islam, Sabina A.
Hay, Christine M.
Hartman, Kelly E.
He, Suqin
Shea, Amy K.
Trocha, Alicja K.
Dynan, Mark J.
Reshamwala, Neha
Buchbinder, Susan P.
Basgoz, Nesli O.
Kalams, Spyros A.
Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
description We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.
author Islam, Sabina A.
Hay, Christine M.
Hartman, Kelly E.
He, Suqin
Shea, Amy K.
Trocha, Alicja K.
Dynan, Mark J.
Reshamwala, Neha
Buchbinder, Susan P.
Basgoz, Nesli O.
Kalams, Spyros A.
author_facet Islam, Sabina A.
Hay, Christine M.
Hartman, Kelly E.
He, Suqin
Shea, Amy K.
Trocha, Alicja K.
Dynan, Mark J.
Reshamwala, Neha
Buchbinder, Susan P.
Basgoz, Nesli O.
Kalams, Spyros A.
author_sort Islam, Sabina A.
title Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
title_short Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
title_full Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
title_fullStr Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
title_full_unstemmed Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
title_sort persistence of human immunodeficiency virus type 1-specific cytotoxic t-lymphocyte clones in a subject with rapid disease progression
publisher American Society for Microbiology
publisher_facet American Society for Microbiology
publishDate 2001
url https://ncbi.nlm.nih.gov/pmc/articles/PMC114246/
https://ncbi.nlm.nih.gov/pubmed/11312363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.10.4907-4911.2001
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