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Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.

Insulin caused the inhibition of glucagon-stimulated adenylate cyclase activity in liver plasma membranes, but failed to inhibit this activity in liver membranes from rats made diabetic by treatment with either alloxan or streptozotocin. Treatment of streptozotocin-diabetic rats with insulin, to nor...

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Bibliografische gegevens
Hoofdauteurs: Gawler, D, Milligan, G, Houslay, M D
Formaat: Artikel
Taal:English
Gepubliceerd in: 1988
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1148735/
https://ncbi.nlm.nih.gov/pubmed/3124829
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