A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.

The Sec7 domain of the guanine nucleotide exchange factor ARNO (ARNO-Sec7) is responsible for the exchange activity on the small GTP-binding protein ARF1. ARNO-Sec7 forms a stable complex with the nucleotide-free form of [Delta17]ARF1, a soluble truncated form of ARF1. The crystal structure of ARNO-...

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Bibliographic Details
Main Authors: Béraud-Dufour, S, Robineau, S, Chardin, P, Paris, S, Chabre, M, Cherfils, J, Antonny, B
Format: Article
Language:English
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170701/
https://ncbi.nlm.nih.gov/pubmed/9649435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.13.3651
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1170701/
https://ncbi.nlm.nih.gov/pubmed/9649435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.13.3651

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