Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor δ (PPARδ) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPARδ(−/−) mice exhibit a striking reduction in adiposity relative to wild-type level...

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Autores principales: Barak, Yaacov, Liao, Debbie, He, Weimin, Ong, Estelita S., Nelson, Michael C., Olefsky, Jerrold M., Boland, Richard, Evans, Ronald M.
Formato: Artículo
Lenguaje:en
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC117556/
https://ncbi.nlm.nih.gov/pubmed/11756685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012610299
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https://ncbi.nlm.nih.gov/pmc/articles/PMC117556/
https://ncbi.nlm.nih.gov/pubmed/11756685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012610299

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