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Anti-phospholamban and protein kinase A alter the Ca2+ sensitivity and maximum velocity of Ca2+ uptake by the cardiac sarcoplasmic reticulum.

The activity of the SERCA2a Ca2+ pump in the sarcoplasmic reticulum (SR) of cardiac muscle is inhibited by phospholamban. When phospholamban is phosphorylated by cyclic-AMP-dependent protein kinase (PKA) this inhibition is relieved. It is generally agreed that this results in an increase in the Ca2+...

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Príomhchruthaitheoirí: Kargacin, M E, Ali, Z, Kargacin, G
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: 1998
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219345/
https://ncbi.nlm.nih.gov/pubmed/9512486
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