The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation.

The crystal structure of the amyloidogenic Leu-55Pro transthyretin (TTR) variant has revealed an oligomer structure that may represent a putative amyloid protofibril [Sebastião, Saraiva and Damas (1998) J. Biol. Chem. 273, 24715-24722]. Here we report biochemical evidence that corroborates the isola...

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Main Authors: Sebastião, M P, Merlini, G, Saraiva, M J, Damas, A M
Format: Artigo
Sprog:English
Udgivet: 2000
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221359/
https://ncbi.nlm.nih.gov/pubmed/10998371
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1221359/
https://ncbi.nlm.nih.gov/pubmed/10998371

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