TY  - JOUR
T1  - A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
A1  - Lev-Ram, Varda
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PB  - The National Academy of Sciences
YR  - 2002
UL  - http://buscaintegrada.pucsp.br/vufind/Record/pubmed-123077
AB  - Long-term depression (LTD) at cerebellar parallel fiber (PF)-Purkinje cell synapses must be balanced by long-term potentiation (LTP) to prevent saturation and allow reversal of motor learning. The only previously analyzed form of cerebellar LTP is induced by 4–8 Hz PF stimulation and requires cAMP but not nitric oxide. It is a poor candidate to reverse LTD because it is presynaptically expressed whereas LTD is postsynaptic. We now characterize a new form of LTP induced by 1 Hz PF stimulation for at least 300 s. This LTP is postsynaptically expressed, enhanced by chelating postsynaptic Ca(2+), and depends on nitric oxide but not cAMP or cGMP, making it a plausible anti-Hebbian counterpart to Hebbian LTD.
KW  - Biological Sciences
KW  - Social Sciences
KW  - Correction
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KW  - Physical Sciences
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