Ultrastructural observations on the basal lamina in the normal human breast.

The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ul...

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Hlavní autoři: Watson, R J, Eyden, B P, Howell, A, Sellwood, R A
Médium: Článek
Jazyk:English
Vydáno: 1988
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1261908/
https://ncbi.nlm.nih.gov/pubmed/3417540
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spelling pubmed-12619082006-10-11 Ultrastructural observations on the basal lamina in the normal human breast. Watson, R J Eyden, B P Howell, A Sellwood, R A J Anat Research Article The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ultrastructural appearances were confirmed: in addition, three morphological variants were found. In all tissue examined, there was reduplication of basal lamina in some areas, which has been described previously as a pathological feature. Also, there was complex branching of the basal lamina into the periductular connective tissue. Some projections contained cytoplasmic processes and, in almost all, hemidesmosomes were seen. The third variant consisted of loops of basal lamina thrown up in folds into the collagenous stromal cuff. Reduplication of basal lamina was detected in breast tissue removed at all stages of the menstrual cycle, looping was not and could not be related to any particular phase of the menstrual cycle. However, complex branching was seen predominantly in the periovulatory and early luteal phase. We conclude that these appearances are normal variants of basal lamina. The appearance of branching basal lamina in the luteal phase suggests that this may be produced in response to endocrine stimulation. 1988-02 /pmc/articles/PMC1261908/ /pubmed/3417540 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Article
spellingShingle Research Article
Watson, R J
Eyden, B P
Howell, A
Sellwood, R A
Ultrastructural observations on the basal lamina in the normal human breast.
description The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ultrastructural appearances were confirmed: in addition, three morphological variants were found. In all tissue examined, there was reduplication of basal lamina in some areas, which has been described previously as a pathological feature. Also, there was complex branching of the basal lamina into the periductular connective tissue. Some projections contained cytoplasmic processes and, in almost all, hemidesmosomes were seen. The third variant consisted of loops of basal lamina thrown up in folds into the collagenous stromal cuff. Reduplication of basal lamina was detected in breast tissue removed at all stages of the menstrual cycle, looping was not and could not be related to any particular phase of the menstrual cycle. However, complex branching was seen predominantly in the periovulatory and early luteal phase. We conclude that these appearances are normal variants of basal lamina. The appearance of branching basal lamina in the luteal phase suggests that this may be produced in response to endocrine stimulation.
author Watson, R J
Eyden, B P
Howell, A
Sellwood, R A
author_facet Watson, R J
Eyden, B P
Howell, A
Sellwood, R A
author_sort Watson, R J
title Ultrastructural observations on the basal lamina in the normal human breast.
title_short Ultrastructural observations on the basal lamina in the normal human breast.
title_full Ultrastructural observations on the basal lamina in the normal human breast.
title_fullStr Ultrastructural observations on the basal lamina in the normal human breast.
title_full_unstemmed Ultrastructural observations on the basal lamina in the normal human breast.
title_sort ultrastructural observations on the basal lamina in the normal human breast.
publishDate 1988
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1261908/
https://ncbi.nlm.nih.gov/pubmed/3417540
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