Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint Cartilage in Immature Rats

Single high oral doses of fluoroquinolones (e.g., 1,200 mg of ofloxacin/kg of body weight) are chondrotoxic in juvenile rats. Characteristic cartilage lesions are detectable as early as 12 h after treatment. Since this dosing regimen does not reflect the therapeutic situation, we studied the effects...

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Bibliographic Details
Main Authors: Lozo, Edith, Riecke, Kai, Schwabe, Rudolf, Vormann, Jürgen, Stahlmann, Ralf
Format: Article
Language:en
Published: American Society for Microbiology 2002
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127237/
https://ncbi.nlm.nih.gov/pubmed/12019086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1755-1759.2002
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https://ncbi.nlm.nih.gov/pmc/articles/PMC127237/
https://ncbi.nlm.nih.gov/pubmed/12019086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1755-1759.2002

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