Human Monocytes Kill Shigella flexneri but Then Die by Apoptosis Associated with Suppression of Proinflammatory Cytokine Production

Shigella flexneri infection of human macrophages is followed by rapid bacterial escape into the cytosol and secretion of IpaB, which activates caspase-1 to mediate cell death and release of mature interleukin (IL)-1β. Here we report a different outcome following infection of human peripheral blood m...

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Autors principals: Hathaway, Lucy J., Griffin, George E., Sansonetti, Philippe J., Edgeworth, Jonathan D.
Format: Article
Idioma:en
Publicat: American Society for Microbiology 2002
Matèries:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC128053/
https://ncbi.nlm.nih.gov/pubmed/12065527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.7.3833-3842.2002
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https://ncbi.nlm.nih.gov/pmc/articles/PMC128053/
https://ncbi.nlm.nih.gov/pubmed/12065527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.7.3833-3842.2002

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