Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations

The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E(2)) concentrations modulate the effects of constant iv infusion of saline vs recombinant human IGF-I on free IGF-I, IGFBP-1 and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. To this end, c...

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Hlavní autoři: Veldhuis, Johannes D., Frystyk, Jan, Iranmanesh, Ali, Ørskov, Hans
Médium: Článek
Jazyk:English
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289262/
https://ncbi.nlm.nih.gov/pubmed/15713723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2004-1314
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spelling pubmed-12892622005-11-23 Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations Veldhuis, Johannes D. Frystyk, Jan Iranmanesh, Ali Ørskov, Hans J Clin Endocrinol Metab Article The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E(2)) concentrations modulate the effects of constant iv infusion of saline vs recombinant human IGF-I on free IGF-I, IGFBP-1 and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. To this end, comparisons were made following administration of placebo (Pl) vs Te in 8 older men (age 61 ± 4 y) and after Pl vs E(2) in 8 postmenopausal women (62 ± 3 y). In the saline session: (i) E(2) lowered and Te increased total IGF-I; (ii) E(2) specifically elevated IGFBP-1 by 1.5-fold and suppressed free IGF-I by 34%; and (iii) E(2) increased binary IGF-I/IGFBP-1 by 5-fold more than Te. During IGF-I infusion: (i) total and free IGF-I rose 1.4–2.0 fold [Pl] and 2.1–2.5 fold [Te] more rapidly in men than women; (ii) binary IGF-I/IGFBP-1 increased 3.4-fold more rapidly in men [Te] than women [E(2)]; and (iii) end-infusion free IGF-I was 1.6-fold higher in men than women. In summary, E(2) compared with Te supplementation lowers concentrations of total and ultrafiltratably free IGF-I and elevates those of IGFBP-1 and binary IGF-I/IGFBP-1, thus putatively limiting IGF-I bioavailability. If free IGF-I mediates certain biological actions, then exogenous Te and E(2) may modulate the tissue effects of total IGF-I concentrations unequally. 2005-02-15 2005-05 /pmc/articles/PMC1289262/ /pubmed/15713723 http://dx.doi.org/10.1210/jc.2004-1314 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Article
spellingShingle Article
Veldhuis, Johannes D.
Frystyk, Jan
Iranmanesh, Ali
Ørskov, Hans
Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations
description The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E(2)) concentrations modulate the effects of constant iv infusion of saline vs recombinant human IGF-I on free IGF-I, IGFBP-1 and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. To this end, comparisons were made following administration of placebo (Pl) vs Te in 8 older men (age 61 ± 4 y) and after Pl vs E(2) in 8 postmenopausal women (62 ± 3 y). In the saline session: (i) E(2) lowered and Te increased total IGF-I; (ii) E(2) specifically elevated IGFBP-1 by 1.5-fold and suppressed free IGF-I by 34%; and (iii) E(2) increased binary IGF-I/IGFBP-1 by 5-fold more than Te. During IGF-I infusion: (i) total and free IGF-I rose 1.4–2.0 fold [Pl] and 2.1–2.5 fold [Te] more rapidly in men than women; (ii) binary IGF-I/IGFBP-1 increased 3.4-fold more rapidly in men [Te] than women [E(2)]; and (iii) end-infusion free IGF-I was 1.6-fold higher in men than women. In summary, E(2) compared with Te supplementation lowers concentrations of total and ultrafiltratably free IGF-I and elevates those of IGFBP-1 and binary IGF-I/IGFBP-1, thus putatively limiting IGF-I bioavailability. If free IGF-I mediates certain biological actions, then exogenous Te and E(2) may modulate the tissue effects of total IGF-I concentrations unequally.
author Veldhuis, Johannes D.
Frystyk, Jan
Iranmanesh, Ali
Ørskov, Hans
author_facet Veldhuis, Johannes D.
Frystyk, Jan
Iranmanesh, Ali
Ørskov, Hans
author_sort Veldhuis, Johannes D.
title Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations
title_short Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations
title_full Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations
title_fullStr Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations
title_full_unstemmed Testosterone and Estradiol Regulate Free IGF-I, IGFBP-1 and Dimeric IGF-I/IGFBP-1 Concentrations
title_sort testosterone and estradiol regulate free igf-i, igfbp-1 and dimeric igf-i/igfbp-1 concentrations
publishDate 2005
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1289262/
https://ncbi.nlm.nih.gov/pubmed/15713723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2004-1314
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