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Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain
PrP knockout mice in which only the open reading frame was disrupted (‘Zürich I’) remained healthy. However, more extensive deletions resulted in ataxia, Purkinje cell loss and ectopic expression in brain of Doppel (Dpl), encoded by the downstream gene, Prnd. A new PrP knockout line, ‘Zürich II’, wi...
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| Auteurs principaux: | , , , , , , |
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| Format: | Article |
| Langue: | en |
| Publié: |
Oxford University Press
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145426/ https://ncbi.nlm.nih.gov/pubmed/11179214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.4.694 |
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