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TAR-RNA binding by HIV-1 Tat protein is selectively inhibited by its L-enantiomer.
An oligoribonucleotide, corresponding to the Tat-interactive top half of the HIV-1 TAR RNA stem-loop, was synthesized in both the natural D- and the enantiomeric L-configurations. The affinity of Tat for the two RNAs, assessed by competition binding experiments, was found to be identical and is redu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado: |
1998
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC147661/ https://ncbi.nlm.nih.gov/pubmed/9611232 |
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