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Central effects produced by injection of 48/80 into the cerebral ventricles of mice
Injections of 20 to 30 μg. of 48/80 into the cerebral ventricular spaces of mice produced a condition of motor excitement termed “delirium ambulatorium.” This condition was aggravated by previous intraperitoneal injection of tranquillizers, atropine, and promethazine, not affected by previous inject...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
1959
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1481809/ https://ncbi.nlm.nih.gov/pubmed/13662582 |
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| Resumo: | Injections of 20 to 30 μg. of 48/80 into the cerebral ventricular spaces of mice produced a condition of motor excitement termed “delirium ambulatorium.” This condition was aggravated by previous intraperitoneal injection of tranquillizers, atropine, and promethazine, not affected by previous injection of mepyramine and abolished by a previous injection of pentobarbitone. When an intraperitoneal injection of strychnine was followed by an intraventricular injection of 48/80, the strychnine convulsions became more violent, but the pattern of delirium ambulatorium was not produced. |
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