Liver X receptor opens a new gateway to StAR and to steroid hormones

Liver X receptors (LXRs) broadly limit cholesterol accumulation by regulating expression of genes involved in cholesterol efflux and storage. In this issue of the JCI, Cummins et al. report that LXRα is involved in similar regulation in the adrenal cortex, but it also substantially modulates glucoco...

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1. Verfasser: Jefcoate, Colin R.
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Sprache:English
Veröffentlicht: American Society for Clinical Investigation 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483167/
https://ncbi.nlm.nih.gov/pubmed/16823483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29160
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spelling pubmed-14831672006-07-04 Liver X receptor opens a new gateway to StAR and to steroid hormones Jefcoate, Colin R. J Clin Invest Commentary Liver X receptors (LXRs) broadly limit cholesterol accumulation by regulating expression of genes involved in cholesterol efflux and storage. In this issue of the JCI, Cummins et al. report that LXRα is involved in similar regulation in the adrenal cortex, but it also substantially modulates glucocorticoid synthesis (see the related article beginning on page 1902). LXRα deletion in mice increases the availability of adrenal cholesterol for steroid synthesis by decreasing the expression of cholesterol efflux transporters. Glucocorticoid synthesis requires intramitochondrial cholesterol transport mediated by the steroidogenic acute regulatory protein (StAR). Surprisingly, LXR deletion and stimulation by an agonist each increase glucocorticoid synthesis. This parallels increased expression of StAR and several other steroidogenic genes. American Society for Clinical Investigation 2006-07-03 /pmc/articles/PMC1483167/ /pubmed/16823483 http://dx.doi.org/10.1172/JCI29160 Text en Copyright © 2006, American Society for Clinical Investigation
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Commentary
spellingShingle Commentary
Jefcoate, Colin R.
Liver X receptor opens a new gateway to StAR and to steroid hormones
description Liver X receptors (LXRs) broadly limit cholesterol accumulation by regulating expression of genes involved in cholesterol efflux and storage. In this issue of the JCI, Cummins et al. report that LXRα is involved in similar regulation in the adrenal cortex, but it also substantially modulates glucocorticoid synthesis (see the related article beginning on page 1902). LXRα deletion in mice increases the availability of adrenal cholesterol for steroid synthesis by decreasing the expression of cholesterol efflux transporters. Glucocorticoid synthesis requires intramitochondrial cholesterol transport mediated by the steroidogenic acute regulatory protein (StAR). Surprisingly, LXR deletion and stimulation by an agonist each increase glucocorticoid synthesis. This parallels increased expression of StAR and several other steroidogenic genes.
author Jefcoate, Colin R.
author_facet Jefcoate, Colin R.
author_sort Jefcoate, Colin R.
title Liver X receptor opens a new gateway to StAR and to steroid hormones
title_short Liver X receptor opens a new gateway to StAR and to steroid hormones
title_full Liver X receptor opens a new gateway to StAR and to steroid hormones
title_fullStr Liver X receptor opens a new gateway to StAR and to steroid hormones
title_full_unstemmed Liver X receptor opens a new gateway to StAR and to steroid hormones
title_sort liver x receptor opens a new gateway to star and to steroid hormones
publisher American Society for Clinical Investigation
publisher_facet American Society for Clinical Investigation
publishDate 2006
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1483167/
https://ncbi.nlm.nih.gov/pubmed/16823483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29160
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