Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

The pathological modifications of α-synuclein (αS) in Parkinson disease and related diseases are poorly understood. We have detected misfolded αS in situ based on the proteinase K resistance (PK resistance) of αS fibrils, and using specific antibodies against S129-phosphorylated αS as well as oxidiz...

Повний опис

Збережено в:
Бібліографічні деталі
Автори: Neumann, Manuela, Kahle, Philipp J., Giasson, Benoit I., Ozmen, Laurence, Borroni, Edilio, Spooren, Will, Müller, Veronika, Odoy, Sabine, Fujiwara, Hideo, Hasegawa, Masato, Iwatsubo, Takeshi, Trojanowski, John Q., Kretzschmar, Hans A., Haass, Christian
Формат: Стаття
Мова:en
Опубліковано: American Society for Clinical Investigation 2002
Предмети:
Article
Онлайн доступ:https://ncbi.nlm.nih.gov/pmc/articles/PMC151810/
https://ncbi.nlm.nih.gov/pubmed/12438441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15777
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Інтернет

https://ncbi.nlm.nih.gov/pmc/articles/PMC151810/
https://ncbi.nlm.nih.gov/pubmed/12438441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15777

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