Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.

The influence of oestrogen on the lupus disease in MRL/l mice has been investigated. Adult, castrated male and female MRL/l mice were administered with s.c. injections of 3.2 micrograms of 17 beta-oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a...

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Egile Nagusiak: Carlsten, H, Tarkowski, A, Holmdahl, R, Nilsson, L A
Formatua: Artikulua
Hizkuntza:English
Argitaratua: 1990
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1535196/
https://ncbi.nlm.nih.gov/pubmed/2372993
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spelling pubmed-15351962007-07-12 Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice. Carlsten, H Tarkowski, A Holmdahl, R Nilsson, L A Clin Exp Immunol Research Article The influence of oestrogen on the lupus disease in MRL/l mice has been investigated. Adult, castrated male and female MRL/l mice were administered with s.c. injections of 3.2 micrograms of 17 beta-oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a potent accelerator of the lupus disease in this mouse strain. Thus, administration of oestrogen accelerates glomerulonephritis, lymphoproliferation and mortality. Our results also indicate that oestrogen exerts a dual effect on the immune system of MRL/l mice by depression of antigen-specific and mitogen-induced T cell responses as well as enhancement of polyclonal B cell activation and autoantibody formation. In addition, even short-term administration of oestrogen in the preclinical phase of the disease resulted in long-lasting effects as evaluated by reduced longevity and aggravation of renal disease. 1990-06 /pmc/articles/PMC1535196/ /pubmed/2372993 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Article
spellingShingle Research Article
Carlsten, H
Tarkowski, A
Holmdahl, R
Nilsson, L A
Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
description The influence of oestrogen on the lupus disease in MRL/l mice has been investigated. Adult, castrated male and female MRL/l mice were administered with s.c. injections of 3.2 micrograms of 17 beta-oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a potent accelerator of the lupus disease in this mouse strain. Thus, administration of oestrogen accelerates glomerulonephritis, lymphoproliferation and mortality. Our results also indicate that oestrogen exerts a dual effect on the immune system of MRL/l mice by depression of antigen-specific and mitogen-induced T cell responses as well as enhancement of polyclonal B cell activation and autoantibody formation. In addition, even short-term administration of oestrogen in the preclinical phase of the disease resulted in long-lasting effects as evaluated by reduced longevity and aggravation of renal disease.
author Carlsten, H
Tarkowski, A
Holmdahl, R
Nilsson, L A
author_facet Carlsten, H
Tarkowski, A
Holmdahl, R
Nilsson, L A
author_sort Carlsten, H
title Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
title_short Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
title_full Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
title_fullStr Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
title_full_unstemmed Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
title_sort oestrogen is a potent disease accelerator in sle-prone mrl lpr/lpr mice.
publishDate 1990
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1535196/
https://ncbi.nlm.nih.gov/pubmed/2372993
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