Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision

Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis into the normally avascular cornea is incompatible with good vision and, therefore, the cornea is one of the few tissues in the human body where avascularity is actively maintained. Here, we provide evidenc...

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Hoofdauteurs: Cursiefen, Claus, Chen, Lu, Saint-Geniez, Magali, Hamrah, Pedram, Jin, Yiping, Rashid, Saadia, Pytowski, Bronislaw, Persaud, Kris, Wu, Yan, Streilein, J. Wayne, Dana, Reza
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Taal:English
Gepubliceerd in: National Academy of Sciences 2006
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Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544098/
https://ncbi.nlm.nih.gov/pubmed/16849433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506112103
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spelling pubmed-15440982007-01-25 Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision Cursiefen, Claus Chen, Lu Saint-Geniez, Magali Hamrah, Pedram Jin, Yiping Rashid, Saadia Pytowski, Bronislaw Persaud, Kris Wu, Yan Streilein, J. Wayne Dana, Reza Proc Natl Acad Sci U S A Biological Sciences Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis into the normally avascular cornea is incompatible with good vision and, therefore, the cornea is one of the few tissues in the human body where avascularity is actively maintained. Here, we provide evidence for a critical mechanism contributing to corneal avascularity. VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis. National Academy of Sciences 2006-07-25 2006-07-18 /pmc/articles/PMC1544098/ /pubmed/16849433 http://dx.doi.org/10.1073/pnas.0506112103 Text en © 2006 by The National Academy of Sciences of the USA
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Biological Sciences
spellingShingle Biological Sciences
Cursiefen, Claus
Chen, Lu
Saint-Geniez, Magali
Hamrah, Pedram
Jin, Yiping
Rashid, Saadia
Pytowski, Bronislaw
Persaud, Kris
Wu, Yan
Streilein, J. Wayne
Dana, Reza
Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
description Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis into the normally avascular cornea is incompatible with good vision and, therefore, the cornea is one of the few tissues in the human body where avascularity is actively maintained. Here, we provide evidence for a critical mechanism contributing to corneal avascularity. VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis.
author Cursiefen, Claus
Chen, Lu
Saint-Geniez, Magali
Hamrah, Pedram
Jin, Yiping
Rashid, Saadia
Pytowski, Bronislaw
Persaud, Kris
Wu, Yan
Streilein, J. Wayne
Dana, Reza
author_facet Cursiefen, Claus
Chen, Lu
Saint-Geniez, Magali
Hamrah, Pedram
Jin, Yiping
Rashid, Saadia
Pytowski, Bronislaw
Persaud, Kris
Wu, Yan
Streilein, J. Wayne
Dana, Reza
author_sort Cursiefen, Claus
title Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
title_short Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
title_full Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
title_fullStr Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
title_full_unstemmed Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
title_sort nonvascular vegf receptor 3 expression by corneal epithelium maintains avascularity and vision
publisher National Academy of Sciences
publisher_facet National Academy of Sciences
publishDate 2006
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1544098/
https://ncbi.nlm.nih.gov/pubmed/16849433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506112103
_version_ 1760322351665250304

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