Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in Xenopus oocytes

1. To investigate the effects of various chemical classes of antipsychotic drugs: haloperidol, thioridazine, pimozide and clozapine, on the G-protein-activated inwardly rectifying K(+) (GIRK) channels, we carried out Xenopus oocyte functional assays with GIRK1 and GIRK2 mRNAs or GIRK1 and GIRK4 mRNA...

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Autores principales: Kobayashi, Toru, Ikeda, Kazutaka, Kumanishi, Toshiro
Formato: Artículo
Lenguaje:English
Publicado: 2000
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571994/
https://ncbi.nlm.nih.gov/pubmed/10780978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703224
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1571994/
https://ncbi.nlm.nih.gov/pubmed/10780978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703224

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