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Human αβ and γδ Thymocyte Development: TCR Gene Rearrangements, Intracellular TCRβ Expression and γδ Developmental Potential – Differences between Men and Mice,

To evaluate the role of the TCR in the αβ/γδ lineage choice during human thymocyte development, molecular analyses of the TCRβ locus in γδ cells and the TCRγ and δ loci in αβ cells were undertaken. TCRβ variable gene segments remained largely in germline configuration in γδ cells, indicating that co...

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Main Authors: Joachims, Michelle L., Chain, Jennifer L., Hooker, Scott W., Knott-Craig, Christopher J., Thompson, Linda F.
Format: Artigo
Jezik:English
Izdano: 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592528/
https://ncbi.nlm.nih.gov/pubmed/16424183
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