Efficacy of Novel Rifamycin Derivatives against Rifamycin-Sensitive and -Resistant Staphylococcus aureus Isolates in Murine Models of Infection

Novel rifamycins (new chemical entities [NCEs]) having MICs of 0.002 to 0.03 μg/ml against Staphylococcus aureus and retaining some activity against rifampin-resistant mutants were tested for in vivo efficacy against susceptible and rifampin-resistant strains of S. aureus. Rifalazil and rifampin had...

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Bibliografiske detaljer
Main Authors: Rothstein, David M. , Farquhar, Ronald S., Sirokman, Klari, Sondergaard, Karen L., Hazlett, Charles, Doye, Angelia A., Gwathmey, Judith K., Mullin, Steve, van Duzer, John, Murphy, Christopher K.
Format: Artigo
Sprog:English
Udgivet: American Society for Microbiology 2006
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635239/
https://ncbi.nlm.nih.gov/pubmed/16940074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01087-05
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1635239/
https://ncbi.nlm.nih.gov/pubmed/16940074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01087-05

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