Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo

The human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G(2). Vpr-expressing cells display the hallmarks of certain forms of DNA damage, specifically activation of the ataxia telangiectasia mutated and Rad3-related kinase, ATR. However, evidence that Vpr fun...

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Bibliografische gegevens
Hoofdauteurs: Zimmerman, Erik S., Sherman, Michael P., Blackett, Jana L., Neidleman, Jason A., Kreis, Christophe, Mundt, Pamela, Williams, Samuel A., Warmerdam, Maria, Kahn, James, Hecht, Frederick M., Grant, Robert M., de Noronha, Carlos M. C., Weyrich, Andrew S., Greene, Warner C., Planelles, Vicente
Formaat: Artikel
Taal:English
Gepubliceerd in: American Society for Microbiology 2006
Onderwerpen:
Virus-Cell Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641771/
https://ncbi.nlm.nih.gov/pubmed/16956949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01212-06
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1641771/
https://ncbi.nlm.nih.gov/pubmed/16956949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01212-06

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