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The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana
The ability to coordinate carbon (C) and nitrogen (N) metabolism enables plants to regulate development and metabolic responses to different environmental conditions. The regulator(s) or sensor(s) that monitor crosstalk between biosynthetic pathways and ultimately control the flow of C or N through...
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pubmed-1645392003-11-28 The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana Kang, Jiman Turano, Frank J. Proc Natl Acad Sci U S A Biological Sciences The ability to coordinate carbon (C) and nitrogen (N) metabolism enables plants to regulate development and metabolic responses to different environmental conditions. The regulator(s) or sensor(s) that monitor crosstalk between biosynthetic pathways and ultimately control the flow of C or N through them have remained elusive. We used an antisense strategy to demonstrate that the putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of C and N metabolism in Arabidopsis. Seeds from AtGLR1.1-deficient Arabidopsis (antiAtGLR1.1) lines did not germinate in the presence of an animal ionotropic glutamate receptor (iGLR) antagonist, but germination was restored upon coincubation with an iGLR agonist or the putative ligand glutamate. In antiAtGLR1.1 lines, endogenous abscisic acid (ABA) concentrations increased with iGLR antagonist treatments and decreased with coincubation with an iGLR agonist, suggesting that germination was controlled by ABA. antiAtGLR1.1 seedlings also exhibited sensitivity to increased levels of Ca(2+) compared with wild type, and they exhibited a conditional phenotype that was sensitive to the C:N ratio. In the presence of C, specifically sucrose, but not glucose, mannitol, or sorbitol, antiAtGLR1.1 seeds did not germinate, but germination was restored upon coincubation with [Formula: see text] , but not [Formula: see text]. Immunoblot, isoenzyme, and RT-PCR analyses indicate that AtGLR1.1 regulates the accumulation of distinct C- and N-metabolic enzymes, hexokinase 1 (HXK1) and zeaxanthin epoxidase (ABA1), by transcriptional control. We provide a model to describe the role of AtGLR1.1 in C/N metabolism and ABA biosynthesis, which in turn controls seed germination. National Academy of Sciences 2003-05-27 2003-05-08 /pmc/articles/PMC164539/ /pubmed/12738881 http://dx.doi.org/10.1073/pnas.1030961100 Text en Copyright © 2003, The National Academy of Sciences |
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Biological Sciences Biological Sciences Biological Sciences Correction Correction Correction Correction Correction Commentary Commentary Commentary Commentary Commentary Commentary Physical Sciences Physical Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Physical Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences |
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Biological Sciences Biological Sciences Biological Sciences Correction Correction Correction Correction Correction Commentary Commentary Commentary Commentary Commentary Commentary Physical Sciences Physical Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Physical Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Kang, Jiman Turano, Frank J. Michael, Todd P. Salomé, Patrice A. McClung, C. Robertson Chen, Lin Zhang, Shaowu Srinivasan, Mandyam V. Raymond, Jason Blankenship, Robert E. Grubmüller, Helmut Gitai, Zemer Shapiro, Lucy Nudo, Randolph J. Sandri-Goldin, Rozanne M. Lindvall, Olle McKay, Ron Sirovich, Lawrence Benzerara, Karim Menguy, Nicolas Guyot, François Dominici, Christian Gillet, Philippe Hanotte, O. Ronin, Y. Agaba, M. Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, S. Gibson, J. Korol, A. Soller, M. Teale, A. Ding, Chunming Cantor, Charles R. Nagatsuka, Yasuko Hara-Yokoyama, Miki Kasama, Takeshi Takekoshi, Masataka Maeda, Fumiko Ihara, Seiji Fujiwara, Shigeyoshi Ohshima, Eriko Ishii, Kumiko Kobayashi, Toshihide Shimizu, Kazufumi Hirabayashi, Yoshio Kim, Hyun Yan, Qi von Heijne, Gunnar Caputo, Gregory A. Lennarz, William J. Beard, Brian C. Wilson, Samuel H. Smerdon, Michael J. Frugier, Magali Giegé, Richard Schimmel, Paul Joët, Thierry Eckstein-Ludwig, Ursula Morin, Christophe Krishna, Sanjeev de Boer, Ernie Rodriguez, Patrick Bonte, Edgar Krijgsveld, Jeroen Katsantoni, Eleni Heck, Albert Grosveld, Frank Strouboulis, John Moskovitz, Jackob Stadtman, Earl R. Das, Sudipto Dixon, Jack E. Cho, Wonhwa Kazantsev, Alexei V. Krivenko, Angelika A. Harrington, Daniel J. Carter, Richard J. Holbrook, Stephen R. Adams, Paul D. Pace, Norman R. Xue, Dahai Shi, Hong Smith, James D. Chen, Xinguo Noe, Dennis A. Cedervall, Tommy Yang, Derek D. Eynon, Elizabeth Brash, Douglas E. Kashgarian, Michael Flavell, Richard A. Wolin, Sandra L. Goldhaber-Gordon, Ilana Early, Michael H. Baker, Tania A. Mao, Jianqiang Chirala, Subrahmanyam S. Wakil, Salih J. Liang, Xue-hai Liu, Qing Michaeli, Shulamit Jiang, Yong Doolittle, Russell F. Nguyen, Jack T. Wells, James A. Bodley, Annette L. Chakraborty, Asit K. Xie, Suji Burri, Christian Shapiro, Theresa A. Sapra, Rajat Bagramyan, Karine Adams, Michael W. W. Kristjuhan, Arnold Wittschieben, Birgitte Ø. Walker, Jane Roberts, Douglas Cairns, Bradley R. Svejstrup, Jesper Q. Ji, Yanhong Zhang, Jianmin Lee, Alfred Ian Cedar, Howard Bergman, Yehudit Oganesian, A. Poot, M. Daum, G. Coats, S. A. Wright, M. B. Seifert, R. A. Bowen-Pope, D. F. Jiang, Zhen Y. Zhou, Qiong L. Coleman, Kerri A. Chouinard, My Boese, Queta Czech, Michael P. Held, G. A. Grinstein, G. Tu, Y. van Noort, John van der Heijden, Thijn de Jager, Martijn Wyman, Claire Kanaar, Roland Dekker, Cees Pitera, Jed W. Swope, William Bosques, Carlos J. Imperiali, Barbara Amaro, Rommie Tajkhorshid, Emad Luthey-Schulten, Zaida Singh-Zocchi, Mukta Dixit, Sanhita Ivanov, Vassili Zocchi, Giovanni Sigg, Daniel Bezanilla, Francisco Stefani, Enrico Lammerding, Jan Kazarov, Alexander R. Huang, Hayden Lee, Richard T. Hemler, Martin E. Farver, Ole Kroneck, Peter M. H. Zumft, Walter G. Pecht, Israel Lu, Quan Hope, Lila Weiqiao Brasch, Michael Reinhard, Christoph Cohen, Stanley N. Ding, Sheng Wu, Tom Y. H. Brinker, Achim Peters, Eric C. Hur, Wooyoung Gray, Nathanael S. Schultz, Peter G. The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana |
| description |
The ability to coordinate carbon (C) and nitrogen (N) metabolism enables plants to regulate development and metabolic responses to different environmental conditions. The regulator(s) or sensor(s) that monitor crosstalk between biosynthetic pathways and ultimately control the flow of C or N through them have remained elusive. We used an antisense strategy to demonstrate that the putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of C and N metabolism in Arabidopsis. Seeds from AtGLR1.1-deficient Arabidopsis (antiAtGLR1.1) lines did not germinate in the presence of an animal ionotropic glutamate receptor (iGLR) antagonist, but germination was restored upon coincubation with an iGLR agonist or the putative ligand glutamate. In antiAtGLR1.1 lines, endogenous abscisic acid (ABA) concentrations increased with iGLR antagonist treatments and decreased with coincubation with an iGLR agonist, suggesting that germination was controlled by ABA. antiAtGLR1.1 seedlings also exhibited sensitivity to increased levels of Ca(2+) compared with wild type, and they exhibited a conditional phenotype that was sensitive to the C:N ratio. In the presence of C, specifically sucrose, but not glucose, mannitol, or sorbitol, antiAtGLR1.1 seeds did not germinate, but germination was restored upon coincubation with [Formula: see text] , but not [Formula: see text]. Immunoblot, isoenzyme, and RT-PCR analyses indicate that AtGLR1.1 regulates the accumulation of distinct C- and N-metabolic enzymes, hexokinase 1 (HXK1) and zeaxanthin epoxidase (ABA1), by transcriptional control. We provide a model to describe the role of AtGLR1.1 in C/N metabolism and ABA biosynthesis, which in turn controls seed germination. |
| author |
Kang, Jiman Turano, Frank J. Michael, Todd P. Salomé, Patrice A. McClung, C. Robertson Chen, Lin Zhang, Shaowu Srinivasan, Mandyam V. Raymond, Jason Blankenship, Robert E. Grubmüller, Helmut Gitai, Zemer Shapiro, Lucy Nudo, Randolph J. Sandri-Goldin, Rozanne M. Lindvall, Olle McKay, Ron Sirovich, Lawrence Benzerara, Karim Menguy, Nicolas Guyot, François Dominici, Christian Gillet, Philippe Hanotte, O. Ronin, Y. Agaba, M. Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, S. Gibson, J. Korol, A. Soller, M. Teale, A. Ding, Chunming Cantor, Charles R. Nagatsuka, Yasuko Hara-Yokoyama, Miki Kasama, Takeshi Takekoshi, Masataka Maeda, Fumiko Ihara, Seiji Fujiwara, Shigeyoshi Ohshima, Eriko Ishii, Kumiko Kobayashi, Toshihide Shimizu, Kazufumi Hirabayashi, Yoshio Kim, Hyun Yan, Qi von Heijne, Gunnar Caputo, Gregory A. Lennarz, William J. Beard, Brian C. Wilson, Samuel H. Smerdon, Michael J. Frugier, Magali Giegé, Richard Schimmel, Paul Joët, Thierry Eckstein-Ludwig, Ursula Morin, Christophe Krishna, Sanjeev de Boer, Ernie Rodriguez, Patrick Bonte, Edgar Krijgsveld, Jeroen Katsantoni, Eleni Heck, Albert Grosveld, Frank Strouboulis, John Moskovitz, Jackob Stadtman, Earl R. Das, Sudipto Dixon, Jack E. Cho, Wonhwa Kazantsev, Alexei V. Krivenko, Angelika A. Harrington, Daniel J. Carter, Richard J. Holbrook, Stephen R. Adams, Paul D. Pace, Norman R. Xue, Dahai Shi, Hong Smith, James D. Chen, Xinguo Noe, Dennis A. Cedervall, Tommy Yang, Derek D. Eynon, Elizabeth Brash, Douglas E. Kashgarian, Michael Flavell, Richard A. Wolin, Sandra L. Goldhaber-Gordon, Ilana Early, Michael H. Baker, Tania A. Mao, Jianqiang Chirala, Subrahmanyam S. Wakil, Salih J. Liang, Xue-hai Liu, Qing Michaeli, Shulamit Jiang, Yong Doolittle, Russell F. Nguyen, Jack T. Wells, James A. Bodley, Annette L. Chakraborty, Asit K. Xie, Suji Burri, Christian Shapiro, Theresa A. Sapra, Rajat Bagramyan, Karine Adams, Michael W. W. Kristjuhan, Arnold Wittschieben, Birgitte Ø. Walker, Jane Roberts, Douglas Cairns, Bradley R. Svejstrup, Jesper Q. Ji, Yanhong Zhang, Jianmin Lee, Alfred Ian Cedar, Howard Bergman, Yehudit Oganesian, A. Poot, M. Daum, G. Coats, S. A. Wright, M. B. Seifert, R. A. Bowen-Pope, D. F. Jiang, Zhen Y. Zhou, Qiong L. Coleman, Kerri A. Chouinard, My Boese, Queta Czech, Michael P. Held, G. A. Grinstein, G. Tu, Y. van Noort, John van der Heijden, Thijn de Jager, Martijn Wyman, Claire Kanaar, Roland Dekker, Cees Pitera, Jed W. Swope, William Bosques, Carlos J. Imperiali, Barbara Amaro, Rommie Tajkhorshid, Emad Luthey-Schulten, Zaida Singh-Zocchi, Mukta Dixit, Sanhita Ivanov, Vassili Zocchi, Giovanni Sigg, Daniel Bezanilla, Francisco Stefani, Enrico Lammerding, Jan Kazarov, Alexander R. Huang, Hayden Lee, Richard T. Hemler, Martin E. Farver, Ole Kroneck, Peter M. H. Zumft, Walter G. Pecht, Israel Lu, Quan Hope, Lila Weiqiao Brasch, Michael Reinhard, Christoph Cohen, Stanley N. Ding, Sheng Wu, Tom Y. H. Brinker, Achim Peters, Eric C. Hur, Wooyoung Gray, Nathanael S. Schultz, Peter G. |
| author_facet |
Kang, Jiman Turano, Frank J. Michael, Todd P. Salomé, Patrice A. McClung, C. Robertson Chen, Lin Zhang, Shaowu Srinivasan, Mandyam V. Raymond, Jason Blankenship, Robert E. Grubmüller, Helmut Gitai, Zemer Shapiro, Lucy Nudo, Randolph J. Sandri-Goldin, Rozanne M. Lindvall, Olle McKay, Ron Sirovich, Lawrence Benzerara, Karim Menguy, Nicolas Guyot, François Dominici, Christian Gillet, Philippe Hanotte, O. Ronin, Y. Agaba, M. Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, S. Gibson, J. Korol, A. Soller, M. Teale, A. Ding, Chunming Cantor, Charles R. Nagatsuka, Yasuko Hara-Yokoyama, Miki Kasama, Takeshi Takekoshi, Masataka Maeda, Fumiko Ihara, Seiji Fujiwara, Shigeyoshi Ohshima, Eriko Ishii, Kumiko Kobayashi, Toshihide Shimizu, Kazufumi Hirabayashi, Yoshio Kim, Hyun Yan, Qi von Heijne, Gunnar Caputo, Gregory A. Lennarz, William J. Beard, Brian C. Wilson, Samuel H. Smerdon, Michael J. Frugier, Magali Giegé, Richard Schimmel, Paul Joët, Thierry Eckstein-Ludwig, Ursula Morin, Christophe Krishna, Sanjeev de Boer, Ernie Rodriguez, Patrick Bonte, Edgar Krijgsveld, Jeroen Katsantoni, Eleni Heck, Albert Grosveld, Frank Strouboulis, John Moskovitz, Jackob Stadtman, Earl R. Das, Sudipto Dixon, Jack E. Cho, Wonhwa Kazantsev, Alexei V. Krivenko, Angelika A. Harrington, Daniel J. Carter, Richard J. Holbrook, Stephen R. Adams, Paul D. Pace, Norman R. Xue, Dahai Shi, Hong Smith, James D. Chen, Xinguo Noe, Dennis A. Cedervall, Tommy Yang, Derek D. Eynon, Elizabeth Brash, Douglas E. Kashgarian, Michael Flavell, Richard A. Wolin, Sandra L. Goldhaber-Gordon, Ilana Early, Michael H. Baker, Tania A. Mao, Jianqiang Chirala, Subrahmanyam S. Wakil, Salih J. Liang, Xue-hai Liu, Qing Michaeli, Shulamit Jiang, Yong Doolittle, Russell F. Nguyen, Jack T. Wells, James A. Bodley, Annette L. Chakraborty, Asit K. Xie, Suji Burri, Christian Shapiro, Theresa A. Sapra, Rajat Bagramyan, Karine Adams, Michael W. W. Kristjuhan, Arnold Wittschieben, Birgitte Ø. Walker, Jane Roberts, Douglas Cairns, Bradley R. Svejstrup, Jesper Q. Ji, Yanhong Zhang, Jianmin Lee, Alfred Ian Cedar, Howard Bergman, Yehudit Oganesian, A. Poot, M. Daum, G. Coats, S. A. Wright, M. B. Seifert, R. A. Bowen-Pope, D. F. Jiang, Zhen Y. Zhou, Qiong L. Coleman, Kerri A. Chouinard, My Boese, Queta Czech, Michael P. Held, G. A. Grinstein, G. Tu, Y. van Noort, John van der Heijden, Thijn de Jager, Martijn Wyman, Claire Kanaar, Roland Dekker, Cees Pitera, Jed W. Swope, William Bosques, Carlos J. Imperiali, Barbara Amaro, Rommie Tajkhorshid, Emad Luthey-Schulten, Zaida Singh-Zocchi, Mukta Dixit, Sanhita Ivanov, Vassili Zocchi, Giovanni Sigg, Daniel Bezanilla, Francisco Stefani, Enrico Lammerding, Jan Kazarov, Alexander R. Huang, Hayden Lee, Richard T. Hemler, Martin E. Farver, Ole Kroneck, Peter M. H. Zumft, Walter G. Pecht, Israel Lu, Quan Hope, Lila Weiqiao Brasch, Michael Reinhard, Christoph Cohen, Stanley N. Ding, Sheng Wu, Tom Y. H. Brinker, Achim Peters, Eric C. Hur, Wooyoung Gray, Nathanael S. Schultz, Peter G. |
| author_sort |
Kang, Jiman |
| title |
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana |
| title_short |
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana |
| title_full |
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana |
| title_fullStr |
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana |
| title_full_unstemmed |
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana |
| title_sort |
putative glutamate receptor 1.1 (atglr1.1) functions as a regulator of carbon and nitrogen metabolism in arabidopsis thaliana |
| publisher |
National Academy of Sciences |
| publisher_facet |
National Academy of Sciences |
| publishDate |
2003 |
| url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC164539/ https://ncbi.nlm.nih.gov/pubmed/12738881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1030961100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164540/ https://ncbi.nlm.nih.gov/pubmed/12736379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1131995100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164541/ https://ncbi.nlm.nih.gov/pubmed/12750474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0732090100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164542/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1231735100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164543/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1232296100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164544/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1131491100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164545/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1232295100 https://ncbi.nlm.nih.gov/pmc/articles/PMC164546/ 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https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0732087100 |
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