Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.

1 The possibility of concanavalin A (Con A) blocking the development of desensitization of nicotinic receptors of the cat adrenal gland has been investigated. 2 During perfusion of the adrenal gland with Krebs-bicarbonate solution containing acetylcholine (ACh), the rate of catecholamine (CA) secret...

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Hauptverfasser: Kirpekar, S M, Prat, J C
Format: Artikel
Sprache:English
Veröffentlicht: 1978
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1668052/
https://ncbi.nlm.nih.gov/pubmed/656698
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spelling pubmed-16680522008-01-10 Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A. Kirpekar, S M Prat, J C Br J Pharmacol Research Article 1 The possibility of concanavalin A (Con A) blocking the development of desensitization of nicotinic receptors of the cat adrenal gland has been investigated. 2 During perfusion of the adrenal gland with Krebs-bicarbonate solution containing acetylcholine (ACh), the rate of catecholamine (CA) secretion was very high in the first 2 min; thereafter, as perfusion with ACh was continued the output fell, to reach about 20% of the initial value in 10 minutes. When the adrenal gland was pretreated with Con A, the subsequent desensitization of release during continued infusion of ACh was prevented. 3 When the adrenal gland was perfused with high K+ solution, there was always a large initial secretion of CA, and as perfusion with high K+ continued the output fell, to reach about 15% of the initial rate in 10 minutes. Con A did not affect the rate of CA secretion induced by high K+. 4 It is tentatively suggested that Con A blocks the desensitization of CA secretion evoked by ACh by interaction with the glycoprotein moiety of the nicotinic receptor of adrenal chromaffin cells. 1978-04 /pmc/articles/PMC1668052/ /pubmed/656698 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Article
spellingShingle Research Article
Kirpekar, S M
Prat, J C
Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.
description 1 The possibility of concanavalin A (Con A) blocking the development of desensitization of nicotinic receptors of the cat adrenal gland has been investigated. 2 During perfusion of the adrenal gland with Krebs-bicarbonate solution containing acetylcholine (ACh), the rate of catecholamine (CA) secretion was very high in the first 2 min; thereafter, as perfusion with ACh was continued the output fell, to reach about 20% of the initial value in 10 minutes. When the adrenal gland was pretreated with Con A, the subsequent desensitization of release during continued infusion of ACh was prevented. 3 When the adrenal gland was perfused with high K+ solution, there was always a large initial secretion of CA, and as perfusion with high K+ continued the output fell, to reach about 15% of the initial rate in 10 minutes. Con A did not affect the rate of CA secretion induced by high K+. 4 It is tentatively suggested that Con A blocks the desensitization of CA secretion evoked by ACh by interaction with the glycoprotein moiety of the nicotinic receptor of adrenal chromaffin cells.
author Kirpekar, S M
Prat, J C
author_facet Kirpekar, S M
Prat, J C
author_sort Kirpekar, S M
title Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.
title_short Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.
title_full Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.
title_fullStr Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.
title_full_unstemmed Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A.
title_sort blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin a.
publishDate 1978
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1668052/
https://ncbi.nlm.nih.gov/pubmed/656698
_version_ 1760338907027734528

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