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A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator
Plasminogen (Pg) activators such as streptokinase (SK) save lives by generating plasmin to dissolve blood clots. Some believe that the unique ability of SK to activate Pg in the absence of fibrin limits its therapeutic utility. We have found that SK contains an unusual NH(2)-terminal “catalytic swit...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artikel |
| Sprache: | en |
| Veröffentlicht: |
The National Academy of Sciences
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC17701/ https://ncbi.nlm.nih.gov/pubmed/10430864 |
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