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Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance
The genome diversity of RNA viruses allows for rapid adaptation to a wide variety of adverse conditions. Accordingly, viruses can escape inhibition by most antiviral compounds targeting either viral or host factors. Here we exploited the capacity of RNA viruses for rapid adaptation to explore the ev...
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| Hauptverfasser: | , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2007
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1770902/ https://ncbi.nlm.nih.gov/pubmed/17234885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1505307 |
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