Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

α-Synuclein (α-SYN) is deposited in intraneuronal cytoplasmic inclusions (Lewy bodies, LBs) characteristic for Parkinson’s disease (PD) and LB dementias. α-SYN forms LB-like fibrils in vitro, in contrast to its homologue β-SYN. Here we have investigated the solubility of SYNs in human LB diseases an...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kahle, Philipp J., Neumann, Manuela, Ozmen, Laurence, Müller, Veronika, Odoy, Sabine, Okamoto, Noriko, Jacobsen, Helmut, Iwatsubo, Takeshi, Trojanowski, John Q., Takahashi, Hitoshi, Wakabayashi, Koichi, Bogdanovic, Nenad, Riederer, Peter, Kretzschmar, Hans A., Haass, Christian
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: American Society for Investigative Pathology 2001
Pynciau:
Regular Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850592/
https://ncbi.nlm.nih.gov/pubmed/11733371
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Rhyngrwyd

https://ncbi.nlm.nih.gov/pmc/articles/PMC1850592/
https://ncbi.nlm.nih.gov/pubmed/11733371

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