Allele-Specific Polymerase Chain Reaction for the Imatinib-Resistant KIT D816V and D816F Mutations in Mastocytosis and Acute Myelogenous Leukemia

Oncogenic mutations of the receptor tyrosine kinase KIT contribute to the pathogenesis of gastrointestinal stromal tumors, systemic mastocytosis (SM), and some cases of acute myelogenous leukemia (AML). The D816V substitution in the activation loop of KIT results in relative resistance to the kinase...

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Hoofdauteurs: Corless, Christopher L., Harrell, Patina, Lacouture, Mario, Bainbridge, Troy, Le, Claudia, Gatter, Ken, White, Clifton, Granter, Scott, Heinrich, Michael C.
Formaat: Artikel
Taal:English
Gepubliceerd in: American Society for Investigative Pathology 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876167/
https://ncbi.nlm.nih.gov/pubmed/17065430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.060089
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1876167/
https://ncbi.nlm.nih.gov/pubmed/17065430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.060089

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