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Tracking Local Conformational Changes of Ribonuclease A Using Picosecond Time-Resolved Fluorescence of the Six Tyrosine Residues

The six tyrosine residues of ribonuclease A (RNase A) are used as individual intrinsic probes for tracking local conformational changes during unfolding. The fluorescence decays of RNase A are well described by sums of three exponentials with decay times (τ(1) = 1.7 ns, τ(2) = 180 ps, and τ(3) = 30...

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Bibliographische Detailangaben
Hauptverfasser: Noronha, Melinda, Lima, João C., Paci, Emanuele, Santos, Helena, Maçanita, António L.
Format: Artikel
Sprache:English
Veröffentlicht: Biophysical Society 2007
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877784/
https://ncbi.nlm.nih.gov/pubmed/17384067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.093625
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