Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes

AIMS: Lansoprazole is a substrate of CYP2C19 and CYP3A. The aim of this study was to compare the inhibitory effects of clarithromycin, an inhibitor of CYP3A on the metabolism of lansoprazole between CYP2C19 genotypes. METHODS: A two-way randomized double-blind, placebo-controlled crossover study was...

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Main Authors:	Saito, Masato, Yasui-Furukori, Norio, Uno, Tsukasa, Takahata, Takenori, Sugawara, Kazunobu, Munakata, Akihiro, Tateishi, Tomonori
Format:	Artigo
Jezik:	English
Izdano:	Blackwell Science Inc 2005
Teme:	Pharmacokinetics/Dosing/Disposition
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1884793/ https://ncbi.nlm.nih.gov/pubmed/15752376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02329.x
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