Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.

1. The cardiovascular effects of (-)-cis-diltiazem, an optical isomer of diltiazem, were studied in the isolated atrium and aortic strip. (-)-cis-Diltiazem (30 microM or more) increased the developed tension of the rat left atrium, while (+)-cis-diltiazem (1 microM or more) decreased it. 2. (-)-cis-...

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Main Authors: Nasa, Y., Ichihara, K., Yoshida, R., Abiko, Y.
Formato: Artigo
Idioma:English
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908429/
https://ncbi.nlm.nih.gov/pubmed/1378343
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spelling pubmed-19084292008-01-10 Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria. Nasa, Y. Ichihara, K. Yoshida, R. Abiko, Y. Br J Pharmacol Research Article 1. The cardiovascular effects of (-)-cis-diltiazem, an optical isomer of diltiazem, were studied in the isolated atrium and aortic strip. (-)-cis-Diltiazem (30 microM or more) increased the developed tension of the rat left atrium, while (+)-cis-diltiazem (1 microM or more) decreased it. 2. (-)-cis-Diltiazem (1 to 100 microM) decreased the rate of spontaneous beating in the right atrium as did (+)-cis-diltiazem. 3. The potency of the positive inotropic action of (-)-cis-diltiazem was almost the same as that of ouabain in the rat left atrium, but in the guinea-pig left atrium it was considerably weaker than that of ouabain. 4. In both endothelium-intact and endothelium-denuded aortic strips, (-)-cis-diltiazem relaxed the Ca(2+)-induced contraction. In the endothelium-intact rat aortic strip depolarized by 15 mM KCl, Bay K 8644, a calcium channel agonist, increased the contractile force, whereas (-)-cis-diltiazem did not. 5. These results indicate that (-)-cis-diltiazem has a positive inotropic action in isolated atria in rats and guinea-pigs, but the mode of positive inotropic action of (-)-cis-diltiazem is different from that of ouabain or Bay K 8644. 1992-03 /pmc/articles/PMC1908429/ /pubmed/1378343 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Article
spellingShingle Research Article
Nasa, Y.
Ichihara, K.
Yoshida, R.
Abiko, Y.
Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
description 1. The cardiovascular effects of (-)-cis-diltiazem, an optical isomer of diltiazem, were studied in the isolated atrium and aortic strip. (-)-cis-Diltiazem (30 microM or more) increased the developed tension of the rat left atrium, while (+)-cis-diltiazem (1 microM or more) decreased it. 2. (-)-cis-Diltiazem (1 to 100 microM) decreased the rate of spontaneous beating in the right atrium as did (+)-cis-diltiazem. 3. The potency of the positive inotropic action of (-)-cis-diltiazem was almost the same as that of ouabain in the rat left atrium, but in the guinea-pig left atrium it was considerably weaker than that of ouabain. 4. In both endothelium-intact and endothelium-denuded aortic strips, (-)-cis-diltiazem relaxed the Ca(2+)-induced contraction. In the endothelium-intact rat aortic strip depolarized by 15 mM KCl, Bay K 8644, a calcium channel agonist, increased the contractile force, whereas (-)-cis-diltiazem did not. 5. These results indicate that (-)-cis-diltiazem has a positive inotropic action in isolated atria in rats and guinea-pigs, but the mode of positive inotropic action of (-)-cis-diltiazem is different from that of ouabain or Bay K 8644.
author Nasa, Y.
Ichihara, K.
Yoshida, R.
Abiko, Y.
author_facet Nasa, Y.
Ichihara, K.
Yoshida, R.
Abiko, Y.
author_sort Nasa, Y.
title Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
title_short Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
title_full Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
title_fullStr Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
title_full_unstemmed Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
title_sort positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
publishDate 1992
url https://ncbi.nlm.nih.gov/pmc/articles/PMC1908429/
https://ncbi.nlm.nih.gov/pubmed/1378343
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