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Different pharmacological profiles of big-endothelin-3 and big-endothelin-1 in vivo and in vitro.
1. Human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) are equipotent as pressor agents and produce a significant change in mean arterial blood pressure (MAP) in anaesthetized guinea-pigs (2 nmol kg-1: peak delta MAP: 23 +/- 6 mmHg and 26 +/- 5 mmHg, respectively). 2. Unlike big-ET-1, big-endo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
1991
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1908550/ https://ncbi.nlm.nih.gov/pubmed/1797310 |
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