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The effects of lectins on the release of EDRF from rabbit aorta.
The effects of the lectins, wheat germ agglutinin (WGA) and concanavalin A (Con A) on endothelium intact pre-contracted rabbit aorta were investigated. WGA (8.3 microM) produced endothelium-dependent relaxations, while Con A (4.3 microM) produced a partially endothelium-dependent relaxation. The end...
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| Автори: | , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
1991
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1908567/ https://ncbi.nlm.nih.gov/pubmed/1665728 |
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| Резюме: | The effects of the lectins, wheat germ agglutinin (WGA) and concanavalin A (Con A) on endothelium intact pre-contracted rabbit aorta were investigated. WGA (8.3 microM) produced endothelium-dependent relaxations, while Con A (4.3 microM) produced a partially endothelium-dependent relaxation. The endothelium-dependent relaxations to WGA were completely reversed by N-acetylglucosamine, haemoglobin and methylene blue and were partially reversed by NG-monomethyl-L-arginine (L-NMMA). It is suggested that WGA works as an agonist in releasing endothelium-derived relaxing factor (EDRF) from the endothelium of rabbit aorta by interacting with a glycosylated receptor on endothelial cells. |
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