Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.

The chemokine receptor CCR5 acts as an essential cofactor for cell entry by macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains, whereas CXCR4 acts as an essential cofactor for T-cell-line-adapted strains. We demonstrated that the specific amino acids in the V3 loop of the HIV-1 en...

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Auteurs principaux: Speck, R F, Wehrly, K, Platt, E J, Atchison, R E, Charo, I F, Kabat, D, Chesebro, B, Goldsmith, M A
Format: Article
Langue:en
Publié: 1997
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC192016/
https://ncbi.nlm.nih.gov/pubmed/9261451
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spelling pubmed-1920162003-10-28 Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop. Speck, R F Wehrly, K Platt, E J Atchison, R E Charo, I F Kabat, D Chesebro, B Goldsmith, M A J Virol Research Article The chemokine receptor CCR5 acts as an essential cofactor for cell entry by macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains, whereas CXCR4 acts as an essential cofactor for T-cell-line-adapted strains. We demonstrated that the specific amino acids in the V3 loop of the HIV-1 envelope protein that determine cellular tropism also regulate chemokine coreceptor preference for cell entry by the virus. Further, a strong correlation was found between HIV-1 strains classified as syncytium inducing in standard assays and those using CXCR4 as a coreceptor. These data support the hypothesis that progressive adaptation to additional coreceptors is a key molecular basis for HIV-1 phenotypic evolution in vivo. 1997-09 /pmc/articles/PMC192016/ /pubmed/9261451 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Speck, R F
Wehrly, K
Platt, E J
Atchison, R E
Charo, I F
Kabat, D
Chesebro, B
Goldsmith, M A
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
description The chemokine receptor CCR5 acts as an essential cofactor for cell entry by macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains, whereas CXCR4 acts as an essential cofactor for T-cell-line-adapted strains. We demonstrated that the specific amino acids in the V3 loop of the HIV-1 envelope protein that determine cellular tropism also regulate chemokine coreceptor preference for cell entry by the virus. Further, a strong correlation was found between HIV-1 strains classified as syncytium inducing in standard assays and those using CXCR4 as a coreceptor. These data support the hypothesis that progressive adaptation to additional coreceptors is a key molecular basis for HIV-1 phenotypic evolution in vivo.
author Speck, R F
Wehrly, K
Platt, E J
Atchison, R E
Charo, I F
Kabat, D
Chesebro, B
Goldsmith, M A
author_facet Speck, R F
Wehrly, K
Platt, E J
Atchison, R E
Charo, I F
Kabat, D
Chesebro, B
Goldsmith, M A
author_sort Speck, R F
title Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
title_short Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
title_full Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
title_fullStr Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
title_full_unstemmed Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
title_sort selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope v3 loop.
publishDate 1997
url https://ncbi.nlm.nih.gov/pmc/articles/PMC192016/
https://ncbi.nlm.nih.gov/pubmed/9261451
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