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Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.
We have developed a system for site-specific DNA integration in human cells, mediated by the adeno-associated virus (AAV) Rep proteins. In its normal lysogenic cycle, AAV integrates at a site on human chromosome 19 termed AAVS1. We describe a rapid PCR assay for the detection of integration events a...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | en |
| 出版: |
1997
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC192153/ https://ncbi.nlm.nih.gov/pubmed/9311886 |
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