Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

The CBL ubiquitin ligase targets a variety of activated tyrosine kinases (TKs) for degradation. Many TKs are mutationally or autocrine activated and/or often overexpressed at the mRNA and protein levels in acute leukemias. We hypothesized that CBL is mutated in patients with acute myeloid leukemia (...

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Hauptverfasser: Caligiuri, Michael A., Briesewitz, Roger, Yu, Jianhua, Wang, Lisheng, Wei, Min, Arnoczky, Kristy J., Marburger, Trent B., Wen, Jing, Perrotti, Danilo, Bloomfield, Clara D., Whitman, Susan P.
Format: Artikel
Sprache:English
Veröffentlicht: American Society of Hematology 2007
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924768/
https://ncbi.nlm.nih.gov/pubmed/17475912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-061176
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1924768/
https://ncbi.nlm.nih.gov/pubmed/17475912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-061176

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