TY  - JOUR
T1  - ppGpp regulation of RpoS degradation via anti-adaptor protein IraP
A1  - Bougdour, Alexandre
LA  - English
PB  - National Academy of Sciences
YR  - 2007
UL  - http://buscaintegrada.pucsp.br/vufind/Record/pubmed-1937563
AB  - IraP is a small protein that interferes with the delivery of σ(S) (RpoS) to the ClpXP protease by blocking the action of RssB, an adaptor protein for σ(S) degradation. IraP was previously shown to mediate stabilization of σ(S) during phosphate starvation. Here, we show that iraP is transcribed in response to phosphate starvation; this response is mediated by ppGpp. The iraP promoter is positively regulated by ppGpp, dependent on the discriminator region of the iraP promoter. Sensing of phosphate starvation requires SpoT but not RelA. The results demonstrate a target for positive regulation by ppGpp and suggest that the cell use of ppGpp to mediate a variety of starvation responses operates in part by modulating σ(S) levels.
KW  - Biological Sciences
ER  -