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Induction and role of regulatory CD4(+)CD25(+) T cells in tolerance to the transgene product following hepatic in vivo gene transfer

Gene replacement therapy is complicated by the risk of an immune response against the therapeutic transgene product, which in part is determined by the route of vector administration. Our previous studies demonstrated induction of immune tolerance to coagulation factor IX (FIX) by hepatic adeno-asso...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cao, Ou, Dobrzynski, Eric, Wang, Lixin, Nayak, Sushrusha, Mingle, Bethany, Terhorst, Cox, Herzog, Roland W.
Formatua: Artikulua
Hizkuntza:English
Argitaratua: American Society of Hematology 2007
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939896/
https://ncbi.nlm.nih.gov/pubmed/17438084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-073304
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