Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introdu...

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Main Authors: Peterson, Jeffrey D., Herzenberg, Leonore A., Vasquez, Kristine, Waltenbaugh, Carl
Formato: Artigo
Idioma:en
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19696/
https://ncbi.nlm.nih.gov/pubmed/9501217
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spelling pubmed-196962001-03-08 Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns Peterson, Jeffrey D. Herzenberg, Leonore A. Vasquez, Kristine Waltenbaugh, Carl Proc Natl Acad Sci U S A Biological Sciences Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introduce glutathione, a tripeptide that regulates intracellular redox and other aspects of cell physiology, as a key regulatory element in this process. By using three different methods to deplete glutathione from T cell receptor transgenic and conventional mice and studying in vivo and/or in vitro responses to three distinct antigens, we show that glutathione levels in antigen-presenting cells determine whether Th1 or Th2 response patterns predominate. These findings present new insights into immune response alterations in HIV and other diseases. Further, they potentially offer an explanation for the well known differences in immune responses in “Th1” and “Th2” mouse strains. The National Academy of Sciences 1998-03-17 /pmc/articles/PMC19696/ /pubmed/9501217 Text en Copyright © 1998, The National Academy of Sciences
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Biological Sciences
spellingShingle Biological Sciences
Peterson, Jeffrey D.
Herzenberg, Leonore A.
Vasquez, Kristine
Waltenbaugh, Carl
Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
description Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introduce glutathione, a tripeptide that regulates intracellular redox and other aspects of cell physiology, as a key regulatory element in this process. By using three different methods to deplete glutathione from T cell receptor transgenic and conventional mice and studying in vivo and/or in vitro responses to three distinct antigens, we show that glutathione levels in antigen-presenting cells determine whether Th1 or Th2 response patterns predominate. These findings present new insights into immune response alterations in HIV and other diseases. Further, they potentially offer an explanation for the well known differences in immune responses in “Th1” and “Th2” mouse strains.
author Peterson, Jeffrey D.
Herzenberg, Leonore A.
Vasquez, Kristine
Waltenbaugh, Carl
author_facet Peterson, Jeffrey D.
Herzenberg, Leonore A.
Vasquez, Kristine
Waltenbaugh, Carl
author_sort Peterson, Jeffrey D.
title Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
title_short Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
title_full Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
title_fullStr Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
title_full_unstemmed Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
title_sort glutathione levels in antigen-presenting cells modulate th1 versus th2 response patterns
publisher The National Academy of Sciences
publisher_facet The National Academy of Sciences
publishDate 1998
url https://ncbi.nlm.nih.gov/pmc/articles/PMC19696/
https://ncbi.nlm.nih.gov/pubmed/9501217
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