TY  - JOUR
T1  - Heat Shock Response in CHO Mammalian Cells Is Controlled by a Nonlinear Stochastic Process
A1  - Lipan, Ovidiu
LA  - English
PB  - Public Library of Science
YR  - 2007
UL  - http://buscaintegrada.pucsp.br/vufind/Record/pubmed-2000973
AB  - In many biological systems, the interactions that describe the coupling between different units in a genetic network are nonlinear and stochastic. We study the interplay between stochasticity and nonlinearity using the responses of Chinese hamster ovary (CHO) mammalian cells to different temperature shocks. The experimental data show that the mean value response of a cell population can be described by a mathematical expression (empirical law) which is valid for a large range of heat shock conditions. A nonlinear stochastic theoretical model was developed that explains the empirical law for the mean response. Moreover, the theoretical model predicts a specific biological probability distribution of responses for a cell population. The prediction was experimentally confirmed by measurements at the single-cell level. The computational approach can be used to study other nonlinear stochastic biological phenomena.
KW  - Research Article
ER  -