Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I

Statins are inhibitors of the rate-limiting enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. In addition to reducing LDL cholesterol, statin treatment increases the levels of the antiatherogenic HDL and its major apolipoprotein apoA-I. Here, we investigated...

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Hoofdauteurs: Martin, Geneviève, Duez, Hélène, Blanquart, Christophe, Berezowski, Vincent, Poulain, Philippe, Fruchart, Jean-Charles, Najib-Fruchart, Jamila, Glineur, Corine, Staels, Bart
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Gepubliceerd in: American Society for Clinical Investigation 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209316/
https://ncbi.nlm.nih.gov/pubmed/11390424
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https://ncbi.nlm.nih.gov/pmc/articles/PMC209316/
https://ncbi.nlm.nih.gov/pubmed/11390424

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