Potential therapeutic role for statins in respiratory disease

Statins reduce cholesterol levels by inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase and have an established role in the treatment of atherosclerotic disease. Recent research has identified anti‐inflammatory properties of statins. Statins appear to reduce the stability of lipid...

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Prif Awduron: Hothersall, E, McSharry, C, Thomson, N C
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: BMJ Group 2006
Pynciau:
Occasional Review
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104700/
https://ncbi.nlm.nih.gov/pubmed/16877692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2005.057976
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spelling pubmed-21047002009-08-01 Potential therapeutic role for statins in respiratory disease Hothersall, E McSharry, C Thomson, N C Thorax Occasional Review Statins reduce cholesterol levels by inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase and have an established role in the treatment of atherosclerotic disease. Recent research has identified anti‐inflammatory properties of statins. Statins appear to reduce the stability of lipid raft formation with subsequent effects on immune activation and regulation, and also prevent the prenylation of signalling molecules with subsequent downregulation of gene expression. Both these effects result in reduced cytokine, chemokine, and adhesion molecule expression, with effects on cell apoptosis or proliferation. This review considers the evidence for the anti‐inflammatory properties of statins in the lung, and how these effects are being applied to research into the role of statins as a novel treatment of respiratory diseases. BMJ Group 2006-08 /pmc/articles/PMC2104700/ /pubmed/16877692 http://dx.doi.org/10.1136/thx.2005.057976 Text en Copyright © 2006 BMJ Publishing Group and British Thoracic Society
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Occasional Review
spellingShingle Occasional Review
Hothersall, E
McSharry, C
Thomson, N C
Potential therapeutic role for statins in respiratory disease
description Statins reduce cholesterol levels by inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase and have an established role in the treatment of atherosclerotic disease. Recent research has identified anti‐inflammatory properties of statins. Statins appear to reduce the stability of lipid raft formation with subsequent effects on immune activation and regulation, and also prevent the prenylation of signalling molecules with subsequent downregulation of gene expression. Both these effects result in reduced cytokine, chemokine, and adhesion molecule expression, with effects on cell apoptosis or proliferation. This review considers the evidence for the anti‐inflammatory properties of statins in the lung, and how these effects are being applied to research into the role of statins as a novel treatment of respiratory diseases.
author Hothersall, E
McSharry, C
Thomson, N C
author_facet Hothersall, E
McSharry, C
Thomson, N C
author_sort Hothersall, E
title Potential therapeutic role for statins in respiratory disease
title_short Potential therapeutic role for statins in respiratory disease
title_full Potential therapeutic role for statins in respiratory disease
title_fullStr Potential therapeutic role for statins in respiratory disease
title_full_unstemmed Potential therapeutic role for statins in respiratory disease
title_sort potential therapeutic role for statins in respiratory disease
publisher BMJ Group
publisher_facet BMJ Group
publishDate 2006
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2104700/
https://ncbi.nlm.nih.gov/pubmed/16877692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2005.057976
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